The LPI-upregulated caspase-1-GSDMD non-canonical secretome had top 10 functional pathways, namely, regulation of nuclease activity, homeostasis of the number of cells, renal cell carcinoma, negative regulation of protein complex assembly, myeloid cell differentiation, CDC5L complex, cellular response to oxidative stress, 7q11.23 copy number variation syndrome, neutrophil degranulation, and nucleotide excision repair (Figure 6B). Here, GSDMD is linked to hereditary clear cell renal cell carcinoma.