GPR55 and hyperlipidemia: Of note, the expression patterns of GPR55 in aortic endothelial cells, fibroblasts, macrophages, and lymphocytes are shared between human aortas and mouse aortas; third, high fat diet-induced hyperlipidemia upregulates aortic GPR55 expression, suggesting critical roles of GPR55 in hyperlipidemia-accelerated atherosclerosis (11, 14, 15, 33, 44, 47, 57, 70, 71).