Among the highly LPI-upregulated TFs, nuclear receptor subfamily 4 group A member 3 (NR4A3) was a novel target of p53 contributing to apoptosis (119); FoxF1 was a therapy target of Hedgehog-related cancers (120); FOS (AP-1 TF subunit) was one of the TFs linked to ERK/MAPK activation (121), inflammation, and atherosclerosis (122); Kruppel-Like Factor 3 (KLF3) was one of the key mechanosensitive master switches in gene expression in promoting atherosclerosis (123); hypoxia-inducible factor-1α (HIF1A) was a master regulator of EC biology for diabetic atherosclerosis (124). The gene discussed is HIF1A; the disease is atherosclerosis.