After adjusting for variables including age, gender, BMI, hypertension, diabetes, dyslipidemia, peripheral arterial disease, current smoker, acute MI, previous PCI, previous MI, family history of CAD, LVEF, eGFR, SYNTAX score, combined CAD, LM ectasia, LAD ectasia, LCX ectasia, RCA ectasia, diffuse dilation, maximum diameter, medications, concomitant revascularization and hsCRP, patients in the high big ET-1 group were still at higher risk of MACE (HR 1.82, 95% CI 1.02–3.25, P = 0.043) in multivariable Cox regression. The gene discussed is EDN1; the disease is coronary artery disorder.