After adjusting for variables including age, gender, BMI, hypertension, diabetes, dyslipidemia, peripheral arterial disease, current smoker, acute MI, previous PCI, previous MI, family history of CAD, LVEF, eGFR, SYNTAX score, combined CAD, LM ectasia, LAD ectasia, LCX ectasia, RCA ectasia, diffuse dilation, maximum diameter, medications, concomitant revascularization and hsCRP, patients in the high big ET-1 group were still at higher risk of MACE (HR 1.82, 95% CI 1.02–3.25, P = 0.043) in multivariable Cox regression. This evidence concerns the gene EDN1 and diabetes mellitus.