When fully adjusted for age, gender, race/ethnicity, education levels, BMI, diabetes history, smoking status, alcohol consumption, sodium intake, triglycerides, total cholesterol levels, albumin, eGFR, and serum phosphorus, increased calcium was significantly associated with the prevalence of hypertension (OR, 1.438; 95%CI, 1.306–1.583). The gene discussed is ALB; the disease is Hypertension.