CCDC151 encodes an axonemal coiled-coil protein, and its mutation blocks CCDC151 from entering respiratory tract cilia, resulting in failed assembly between the ODA component DNAH5 and the ODA-related components CCDC114 and ARMC4 in axons (Hjeij et al., 2014), causing ciliary dyskinesia. The gene discussed is ODAD2; the disease is primary ciliary dyskinesia.