It has been reported that ARMC12 interacts with RBBP4 and promotes the formation and activity of polycomb repressive complex 2, which leads to transcriptional inhibition of tumor suppressor genes (CADM1, EGLN3, HRK, HS6ST3, SMAD9) and thus the promotion of NB proliferation (Li et al., 2018). Here, ARMC12 is linked to neuroblastoma.