The expression of ARMC3 is significantly increased in highly active sperm (D’Amours et al., 2019), whereas the deletion of exon 11 of the ARMC3 gene may alter the reading frame, leading to premature termination of translation, which causes sperm defects and thus male infertility (Pausch et al., 2016). Here, ARMC3 is linked to male infertility.