APP is an amyloid-beta precursor protein that induces the clusterin/p53/Dkk1/Wnt/PCP/JNK pathway, which drives the upregulation of several genes, including EGR1, NAB2, and KLF10, to mediate neurotoxicity and tau phosphorylation and thus promotes the development of neuropathologies observed in AD (Killick et al., 2014). The gene discussed is CLU; the disease is Alzheimer disease.