On the one hand, in mammalian cells, ARMC8 is a key component of the C-terminal of lissencephaly type-1-like homology motif (CTLH) complex, which has E-3 ligase activity and is related to all basic biological processes and functions of the PI3 kinase, Wnt, TGF-β, and NF-κB pathways to regulate proliferation, survival, programmed cell death, cell adhesion, migration and other activities (Huffman et al., 2019). Here, ARMC8 is linked to classic lissencephaly.