CDH1 and hepatocellular carcinoma: For example, regarding cell adhesion and tumor metastasis, ARMC8 upregulates matrix metalloproteinase-7 and Snail and degrades α-catenin to disrupt the α-catenin/E-cadherin complex and promote the migration and invasion of hepatocellular carcinoma, breast cancer, lung adenocarcinoma, osteosarcoma, hepatocellular carcinoma, ovarian cancer, bladder cancer, colon cancer, and others (Jiang et al., 2015a; Jiang et al., 2015b; Zhao et al., 2016; Gul et al., 2019).