SPARC and familial pancreatic carcinoma: For example, the higher levels of SPARC expression have been reported in breast cancer (Lien et al., 2007) and glioblastomas (Rempel et al., 1998), while the lower levels of SPARC expression have been found in ovarian (Yiu et al., 2001), colorectal (Yang et al., 2007; Cheetham et al., 2008), and pancreatic cancers (Puolakkainen et al., 2004).