(iii) Illustrating the prominent role of acquired factors (monoclonal gammopathy, C3 nephritic factor, and FH autoantibody) in C3G even though a rare variant was identified but demonstrated normal function (Patients 6 and 7) (iv) Formulating an informed therapeutic decision about a potential living donor transplantation in the setting of a TMA (Patient 8). The gene discussed is C3; the disease is monoclonal gammopathy.