In some cases, endothelial cell (EC) injury predominates, for instance the hemolytic uremic syndrome (HUS) (1), thrombotic thrombocytopenic purpura (TTP) (2), pre-eclampsia (3, 4), and nephrotoxicity due to VEGF inhibitors (5). This evidence concerns the gene VEGFA and thrombotic thrombocytopenic purpura.