NLRP3 inflammasome is key to a variety of disease processes: from the first identified familial recurrent auto-inflammatory responses to type 2 diabetes, Alzheimer’s disease, and atherosclerosis (Yu et al., 2017; Li et al., 2018; Liu et al., 2019; Lu et al., 2019). This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.