CDH1 and infection: As for otitis media, CDH1 has been shown to participate in the pathogenesis of otitis media via regulation on the inflammatory proliferative responses against infections (Kurabi et al., 2013).Therefore, although both subtypes of hearing loss have been shown to be associated with gene CDH1, the contribution and regulatory role of CDH1 on them are totally different, reflecting the complex regulatory mechanisms for childhood hearing loss.