Furthermore, the genes within the B to A compartment switching regions were significantly involved in the calcium signaling pathway, a highly versatile intracellular signal being capable of regulating many different processes (Berridge, 2012), as well as the TGF-β signaling pathway, which could multifunctionally regulate many cellular processes including cell growth, cell differentiation, apoptosis, morphogenesis, immune regulation, wound healing, inflammation, and cancer in both adult organisms and developing embryos (Morikawa et al., 2016). This evidence concerns the gene TGFB1 and cancer.