In endometrial cancer (EC) VEGF and MMPs play a major role in tumor growth and metastasis since MMP-2 and -9 are persistently upregulated in EC although the expression levels are closely associated with the clinical stage, tumor invasion, and metastasis of the disease (Mahecha and Wang, 2017; Liu et al., 2018). The gene discussed is VEGFA; the disease is neoplasm.