For example, the classical chemotherapeutic drug paclitaxel can further regulate glutamate catabolism (one of the pathways through which ferroptosis occurs) in colorectal cancer cells by reducing the expression of intracellular glutamate-catabolism-related genes such as SLC7A11 and SLC1A5 and inducing an increased expression of P53 and P21, which altogether inhibit tumour growth (Lv et al., 2017). The gene discussed is TP53; the disease is neoplasm.