Another study reported that TFE3 mRNA levels are higher than those of TFEB in human hippocampus tissue, and it further demonstrated that TFE3 but not TFEB plays a prominent role in promoting lysosomal biogenesis and autophagy upregulation in CA1 neurons during Alzheimer’s disease pathogenesis (Bordi et al., 2016). Here, TFEB is linked to early-onset autosomal dominant Alzheimer disease.