Lysosomal dysfunction was indicated by decreased protein levels of Lysosomal-associated membrane protein type 1 (Lamp1), a lysosomal marker, and Cathepsin D (CatD), a lysosomal protease, in the SN of PD patients (Chu et al., 2009; Dehay et al., 2010). This evidence concerns the gene LAMP1 and Parkinson disease.