Regarding the molecular basis of FL-HCC, a fusion of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1) with the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has often been found in such tumors, but its cancer driving property had not been proven yet. This evidence concerns the gene PRKACA and hepatocellular carcinoma.