Most downregulated RBPs include PAIP2B, SIDT2, PDCD4, AZGP1, and RNASE1, among which we report for the first-time involvement of PAIP2B, SIDT2, PDCD4, and RNASE1 in pancreatic cancer (Figure 2). The gene discussed is PAIP2B; the disease is familial pancreatic carcinoma.