Most downregulated RBPs include PAIP2B, SIDT2, PDCD4, AZGP1, and RNASE1, among which we report for the first-time involvement of PAIP2B, SIDT2, PDCD4, and RNASE1 in pancreatic cancer (Figure 2). This evidence concerns the gene RNASE1 and familial pancreatic carcinoma.