EGF and neoplasm: Moreover, TGF- β is not the sole inducer of EMT, and in the tumor microenvironment, there are other paracrine signaling pathways such as WNT pathway, NOTCH signaling, and mitogenic growth factor such as EGF and FGF-mediated activation pathways acting in combination to induce an EMT program (Dongre and Weinberg, 2019).