SERPINE1 and neoplasm: For example, tumor-derived PAI-1 promotes the migration of monocytes and polarizes tumor-associated macrophages (TAMs) towards proinflammatory phenotypes (7), leading to the production of proinflammatory and angiogenesis-promoting factors such as IL-1, IL-8, CCL2, CCL3, CCL5, and VEGF (11).