Aberrations detected with Fluorescence in situ hybridization (FISH), namely the Döhner hierarchical model, have for the last 20 years served as the backbone of CLL diagnostics, dictating the treatment choice, together with the mutation status of TP53 gene and also the segregation into mutated- and unmutated-CLL (M-CLL and U-CLL respectively) (10, 11). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.