In HEK293 cells without PD-L1 expression, rU1 snRNPA, as an inhibitor of PD-L1, had almost no reactivation of tumor-suppressed T cells or killing activity, which can preliminarily prove that rU1 snRNPA had specificity of targeting PD-L1 to exert anti-cancer activity. The gene discussed is SFMBT1; the disease is neoplasm.