In the gene-specific subgroup analysis, the diagnostic accuracy of combined TBR/ADC was significantly higher than that of each imaging mode for gliomas with IDH1 mutation (Figure 6B; AUC, 0.742 vs. 0.690 [TBRmean] and 0.500 [ADC]), so as for hTERT (Figure 6C; AUC, 0.850 vs. 0.711 [TBRmean] and 0.827 [ADC]) and EGFR mutations (Figure 6H; AUC, 0.815 vs. 0.601 [TBRmean] and 0.798 [ADC]). This evidence concerns the gene EGFR and central nervous system cancer.