MGMT and central nervous system cancer: In addition, several molecular markers, including isocitrate dehydrogenase 1 (IDH1), epidermal growth factor receptor (EGFR), O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, telomerase reverse transcriptase (TERT), 1p/19q codeletion, phosphatase and tensin homolog (PTEN), and α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX), have been shown to be glioma prognostic factors (4–7), and their threshold values have been validated clinically.