Figure S7 showed that distribution of the 20 most frequently mutated genes and clinical features in the TCGA-OSCC patients. In the TCGA-HNSCC dataset, USP9X mutation was found to be associated with poor OS (log-rank P = 0.010, Figure S8C). CASP8 mutation was marginal significantly associated with OS (log-rank P = 0.070, Figure S8C). However, there were no significant differences in OS between CUBN mutation group and non-CUBN mutation group (log-rank P =0.885, Figure S8B). This evidence concerns the gene CASP8 and head and neck squamous cell carcinoma.