The intersection between the 1280 related genes and genes of pathways in cancer and VEGF signaling pathways highlighted six genes: PIK3CD, PIK3CG, PIK3R5, PLCG2, RAC2, and VEGFA. Further analyses on the relationship between these genes and apoptosis, natural killer cell mediated cytotoxicity and JAK-STAT signaling pathways showed that PIK3CD, PIK3CG, and PIK3R5 were common key genes (Supplementary Figure 2). Here, RAC2 is linked to cancer.