PLAG1 and obesity due to melanocortin 4 receptor deficiency: By examination of exon 1 of the PLAG1 gene, region 8:56211059–56211208 (genome reference sequence: GRCh38.p13): An increase in PLAG1 expression was linked to a higher BF percentage. The FTO gene is considered to be involved in the development of obesity in children, as well as the coexisting dysfunction of glucose-lipid metabolism.