Rhegmatogenous retinal detachment (RRD) induces ischemic conditions of photoreceptor, which triggers the expression of many growth factors and cytokines, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), hepatocyte growth factor, epidermal growth factor, transforming growth factors α and β, granulocyte-colony stimulating factor, fibroblast growth factors, insulin-like growth factor-I, cytokines (interleukin- (IL-) 1, IL-6, IL-8, IL-10, and interferon γ), matrix metalloproteinase, and chemokine in the vitreous and subretinal fluid [1–3]. Here, VEGFA is linked to rhegmatogenous retinal detachment.