PDE-5 (phosphodiesterase) inhibitors are characterized by various effects such as protecting or enhancing vascular endothelial function and improving hemodynamics.5 It was considered in the study of Lee et al.6 that hyperlipidemia was associated with the risk of ED, and tadalafil, a new generation of PDE-5 (phosphodiesterase) inhibitor, had a certain synergistic effect on the improvement of hemodynamics in patients with hyperlipidemia. Here, PDE5A is linked to hyperlipidemia.