NT-proBNP is the gold standard for the diagnosis of heart failure, and can be used to determine the prognosis of heart failure.13 In this experiment, the correlation analysis between ficolin-3 and NT-proBNP shows that ficolin-3 is negatively correlated with NT-proBNP, indicating that ficolin-3 is likely to be used as a new index for the prognosis of heart failure. The gene discussed is NPPB; the disease is heart failure.