However, the HGI release 6 in June 2021 identified 5 variants reaching statistical significance within the CCHCR1 gene, situated 110 kb downstream of HLA-C (top SNP: rs111837807, p-value = 2.2 × 10−11, ORmeta 1.23) as well as a variant within HLA-DPB1 3′UTR (rs9501257, p-value = 4.1 × 10−8, ORmeta 1.19), when comparing the general population to patients with critical COVID-19 (ncases = 8,779, ncontrol = 1,001,875, from 25 studies of various ancestries). This evidence concerns the gene HLA-C and COVID-19.