In our study, some lncRNAs could co-express with pituitary-specific genes like GH1, GHRHR, PRLHR, FSHB, and LHB. Some other lncRNAs could co-express with genes involved in EVs’ marker protein, protein transport, and docking such as CD63, CD81, TSG101, Rab27A, Rab27B, and UBL3. On the other hand, the signal of a two-circRNA was found to be able to predict tumor recurrence in clinically non-functioning pituitary adenoma (Guo et al., 2019). Here, GHRHR is linked to pituitary gland adenoma.