On the other hand, gene mutations at Vps13d codon 295 and Tgfbr2 codon 549, which were found in DMBA-treated organoids and/or the DMBA-treated organoid-derived adenocarcinomas were not observed in mammary adenocarcinomas induced by oral DMBA treatment of the heterozygous BALB/c-Trp53 knockout mice. The gene discussed is TGFBR2; the disease is adenocarcinoma.