In mammary carcinomas induced in female Sprague-Dawley rats by a single oral dose of DMBA, hormone receptors (HRs), such as the estrogen receptor α (ERα) and/or the progesterone receptor, exhibited positive (Alvarado et al., 2017) and frequent Hras mutations in codon 61 (El-Sohemy and Archer, 2000). The gene discussed is ESR1; the disease is breast carcinoma.