KIF11 and hearing loss disorder: Unexpectedly, we found that these two hearing-loss-associated variants and the current variant in KIF11 (Figure 4A) are all mapped to a small region within a single β-sheet (amino acids 235–245, Figure 4B) in the catalytic domain of Kinesin motor (Smart Motif: mart.embl-heidelberg.de; PDB database: 3K5E), suggesting a specific portion of the protein implicated in hearing function.