ACE2 and endothelial dysfunction: As a result, ACE2 is seen as a double-edged sword in which in normal people the activation of ACE-dependent pathway upon SARS-CoV-2 infection leads to reduced expression of ACE2 that in turn results in ARDS and endothelial dysfunction, while in individuals with comorbidities leads to coagulation, inflammation, and damage to lungs and brain (49–51).