Eosinophils define the disease in EoE, but the inflammation in EoE is more complex and all the other cell types of atopic inflammation such as basophils, mast cells, IgE producing B cells, innate Lymphocytes type 2 (IL2), invariant natural killer cells (iNKTs) have been shown to be important players (197, 204). This evidence concerns the gene IGHE and eosinophilic esophagitis.