Several single nucleotide polymorphisms (SNPs) of epithelial genes promoting Th2 inflammation such as eotaxin-3 (CCL26) on 7q11.23, thymic stromal lymphopoietin (TSLP) on 5q22, and Toll-like receptor 3 (TLR3) on 4q35.1, have been connected to EoE by several independent groups (218, 221, 222). This evidence concerns the gene TLR3 and eosinophilic esophagitis.