Indeed, biologics directed against IgE (omalizumab) and eosinophils (anti-IL-5 reslizumab and mepolizumab) have been shown to control asthma in patients with allergic sensitisation and an eosinophilic endotype (211, 212) but have not been proven to be helpful in EoE (213, 214). The gene discussed is IGHE; the disease is eosinophilic esophagitis.