Variations in the ORMDL3/GSDMB locus, and GSDMB, CD14, CC16, CYSLTR1, ST2, GSTP1, and IL1RL1 genes among others (123–129), some of which may be epithelium and innate immunity specific have also been shown to be associated with childhood onset asthma. Here, IL1RL1 is linked to childhood onset asthma.