Several studies have investigated the role of RGS10 in inflammation-associated diseases, such Parkinson’s disease (23), multiple sclerosis (33), thioglycolate-induced peritonitis (19), osteopetrosis (34–36), cardiac hypertrophy (37), chemoresistant ovarian cancer (38–41), platelets aggregation and thrombogenesis (42–46), obesity and related metabolic syndromes (47), rheumatoid arthritis (48), and colitis-related neurologic dysfunction (49). Here, RGS10 is linked to obesity due to melanocortin 4 receptor deficiency.