NLRP3 and fungal infectious disease: marneffei yeasts into mice with C57BL/6 background showed that 10 out of 12 wild type mice eventually succumbed to fungal infection in spite of significantly prolonged survival time compared to Nlrp3-/- mice, implying that establishment of T. marneffei infection model at a lower dose that at least half of wild type mice survive would be more convinced to demonstrate the important role of NLRP3 in defense against its infection in the following study.