NLRP3 and infection: Another limitation of this study is that our experimental design involves a murine systemic talaromycosis model which represents the advanced stage of T. marneffei infection; how conidia-yeasts transition in the airway epithelium impacts on the activation of NLRP3 inflammasome and induction of adaptive T-cell response at the earlier stage of infection requires animal studies using intranasal instillation technique for delivery of T. marneffei conidia.