Anti-MCH antibody suppressed the production of fibrotic genes in experimental colitis (14), and oral administration of MCHR1 antagonist decreased Col1α1 and TGFβ1 expression levels in a dose-dependent manner in the liver of C57BL/6 J mice with severe hepatic steatosis (16). The gene discussed is TGFB1; the disease is Hepatic steatosis.