TGFB1 and systemic sclerosis: BLM is reported to induce pro-inflammatory cytokines such as TGFβ1 and CTGF in human dermal fibroblasts in vitro (43), suggesting that the combination of several pro-inflammatory mediators, even in the presence of TGFβ1, can increase the expression of MCHR1, consistent with our data in SSc dermal fibroblasts showing high levels of MCHR1.