We aimed to elucidate the relevance of insulin sensitivity alteration pattern in GDM subtypes to the circulating FGF21 concentration at delivery, to further investigate the FGF21 signaling in visceral WAT (vWAT) at delivery, and hope to provide individualized FGF21-targeted treatment for GDM women according to their specialized subtype. The gene discussed is FGF21; the disease is gestational diabetes.