Umbellulone, on the other hand, reversed the CSD suppression produced by ROS inhibitor and both ROS and TRPA1 activation overturned the decreased cortical susceptibility to CSD by the anti-CGRP (calcitonin gene-related peptide) antibody, indicating that ROS/TRPA1/CGRP signaling regulates cortical susceptibility to CSD leading to migraine (48). This evidence concerns the gene TRPA1 and migraine disorder.