The phenotype of nitrogen permease regulator-like 2 (<i>NPRL2</i>) gene-related epilepsy clinically manifests as a range of epilepsy syndromes, including familial focal epilepsy with variable foci (FFEVF), sleep-related hypermotor epilepsy (SHE), temporal lobe epilepsy (TLE), frontal lobe epilepsy (FLE), and infantile spasms (IS). This evidence concerns the gene NPRL2 and sleep-related hypermotor epilepsy.