Kaito et al. found that the blood monocytes increased within 0–16 days after the occurrence of an acute ischemic stroke event, among which CD14(high)CD16(–) classical and CD14(high)CD16(+) intermediate monocytes increased significantly from 0 to 7 and 3 to 16 days after stroke, respectively, while CD14(+)CD16(high) non-classical monocytes decreased during 0–7 days after stroke (32). This evidence concerns the gene CD14 and stroke disorder.