CPEB4 and Hyperglycemia: In addition, HFD-fed and CPEB4 KO mice showed hyperglycemia, and although CPEB4 KO was not directly related to glucose metabolism, it is indirectly associated to it through impaired lipid homeostasis, as the accumulation of lipids has an inhibitory effect on hepatic insulin signaling (Maillo et al., 2017), leaving liver gluconeogenesis unaffected.