Although this mechanism has not yet been studied in a HCC context, it is worthy to bear in mind that Twist1 is activated under hypoxic circumstances (Sun et al., 2009), when HIF1a is also active and not repressed by CPEB1 and CPEB2 (Hägele et al., 2009; Chen and Huang, 2012), a situation that could be perfectly given in a tumoral and fibrotic environment lacking nutrient and oxygen influx. Here, CPEB1 is linked to hepatocellular carcinoma.