In this study, they uncovered a mechanism by which depletion of CPEB1 causes a substantial increase in macrophage IL-6 synthesis, a well characterized pro-inflammatory cytokine with an active role both in chronic inflammation in a context of obesity and HCC progression (Alexandrov et al., 2012; Taniguchi and Karin, 2014; Ramirez-Pedraza and Fernández, 2019). This evidence concerns the gene CPEB1 and obesity due to melanocortin 4 receptor deficiency.