While CPEB4 is physiologically expressed in the brain, heart, kidney and lung (Ortiz-Zapater et al., 2012), it has been the most related CPEB to HCC, although its role comes as quite paradoxical; whilst it seems to play a tumor-suppressor role in HCC, it’s been described as an oncogenic promoter in other kinds of cancer (Tsai et al., 2016). Here, CPEB1 is linked to hepatocellular carcinoma.