The in vivo part of this study included HFD-fed mice; they observed that not only KO mice exhibited more IL-6 compared to WT, but also that HFD-fed KO mice presented insulin resistance, which has been many times related to chronic inflammation in literature, and also related to CPEB1 and CPEB2 depletion (Alexandrov et al., 2012). The gene discussed is CPEB1; the disease is Insulin resistance.