CPEB1 and Insulin resistance: Other interactions described in literature that may potentially play a role in chronic liver disease initiation are, for example, CPEB1 on PTEN and STAT3 mRNAs; though CPEB1 interacts in a direct manner with these CPE-containing mRNAs by repressing them, in the absence of CPEB1 these factors become upregulated, interfering in glucose metabolism and causing insulin resistance in the liver in response to stressful ongoing events, such as high fat diet (Alexandrov et al., 2012).