IL6 and Insulin resistance: The in vivo part of this study included HFD-fed mice; they observed that not only KO mice exhibited more IL-6 compared to WT, but also that HFD-fed KO mice presented insulin resistance, which has been many times related to chronic inflammation in literature, and also related to CPEB1 and CPEB2 depletion (Alexandrov et al., 2012).