Hillers-Ziemer et al. (2020) found that tumors grown within obese mice had increased expression of cancer stem cell-associated genes, such as SOX2 and NOTCH2, compared to those in lean mice. Additionally, Bowers et al. (2018) found that leptin signaling, which is increased in obASCs, contributes to obesity-mediated CSC enrichment. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.