Our results further demonstrated that mitochondrial fission is increased and fusion is decreased in the heart of rat with NG-HTN, which are in accordance with the data presented with FIS1 and OPA1 that further corroborates with increased fission and decreased fusion events of the mitochondria in the heart of NG-HTN (Papanicolaou et al., 2011; Ikeda et al., 2015). This evidence concerns the gene FIS1 and hypertensive disorder.