Levels of TOM20 are decreased in NG-HTN, while levels of TIM17 are increased (Figures 7E,F), which indicates an altered mitochondrial protein import efficiency and YME1L1 protease activation (Rainbolt et al., 2013; Figures 8C,F) and thus associated with the overall compromised mitochondrial proteostasis in the hearts of rats with NG-HTN. Here, YME1L1 is linked to hypertensive disorder.