Previously we reported (Noël et al., 2017) that pulmonary alveoli were significantly enlarged and that Serpina1a, the mouse ortholog of the human gene alpha-1 antitrypsin (α1AT) – a known genetic risk factor for emphysema – was significantly down-regulated in 15-week-old female mouse offspring that had been exposed solely to SHS in utero. Here, SERPINA1 is linked to pulmonary emphysema.