MMP12 and non-small cell lung carcinoma: Mmp12, which was up-regulated by 9.3-fold in the in utero SHS plus urethane group (Figure 13B), has been found to be significantly increased in lung tumors, including NSCLC in humans (Hofmann et al., 2005; Shah et al., 2010; Eide et al., 2016; Ella et al., 2018).