In contrast, our data in adult mice exposed in utero to SHS, which is orders of magnitude lower than CS in terms of exposure levels, showed that in utero SHS exposures upregulate the adult lung gene and protein expression of MMP12 in the offspring, associated with the onset of emphysema, asthma, and lung cancer (Figures 2–14). The gene discussed is MMP12; the disease is pulmonary emphysema.