In general, most renal drug transporters are not affected by a long-term administration of a high-fat diet, but decreased expressions of the uptake protein OAT1/3 was observed in the kidney (Lu et al., 2019), which can lead to an accumulation of endogenous toxic substances that may contribute to obesity-related diseases, such as hyperlipidemia, NAFLD, CKD, and diabetes. The gene discussed is SLC22A6; the disease is diabetes mellitus.