In an acute lymphoblastic leukemia mice model, the MRP 2/4 levels and the clearance of MRP-mediated drugs were significantly reduced, but the MDR1, OAT3, and OCT2 levels were increased, corresponding to the increased clearances of MDR1-mediated digoxin, OAT3-mediated furosemide, and OCT2-mediated metformin (Zhou et al., 2020a). This evidence concerns the gene SLC22A8 and acute lymphoblastic leukemia.