AKT1 and cancer: Based on the results of KEGG enrichment, as shown in Table 4, multiple pathways jointly contributed to the antiONFH effect of BTP, including the PI3k-Akt signaling pathway, prostate cancer, pathways in cancer, the cell cycle, the estrogen signaling pathway, protein processing in the endoplasmic reticulum, hepatitis c, proteoglycans in cancer, the central carbon metabolism in cancer, small-cell lung cancer, progesterone-mediated oocyte maturation, endocrine resistance, oocyte meiosis, fluid shear stress and atherosclerosis, and breast cancer.