MAPT and supranuclear palsy, progressive, 1: Furthermore, the inferior temporal gyrus, where a high density of paired helical filament-tau and associated gliosis have been observed in AD (Harada et al., 2018), was a good region to differentiate AD from PSP and CBS, because patients with AD showed higher retention of 18F-THK5351 in the region compared to those with CBS and PSP (Figure 2B).