However, despite promising preclinical findings, clinical trials targeting CRF and CRF1 have shown limited or negligent success in treating a range of psychiatric conditions, including SUD (Lijffijt et al., 2014), anxiety and depressive, and neurodegenerative disorders (Sanders and Nemeroff, 2016; Spierling and Zorrilla, 2017). Here, CRH is linked to Anxiety.