IL6R and amyotrophic lateral sclerosis: In 2012, Mizwicki et al. provided evidence for attenuation of inflammatory activation in the peripheral blood mononuclear cells (PBMCs) and in the CSF of ALS patients through inhibition of IL-6R by treatment with Tocilizumab, a humanized antibody (HuAb) against IL-6R (Mizwicki et al., 2012).