Although Cd and AD each have been shown to impact the xenobiotic and energy metabolism of liver and other metabolic organs, very little is known regarding to the extent that cadmium and the ApoE genotype interact to modulate the xenobiotic and intermediary metabolism pathways within the gut-liver axis, and how changes in the hepatic gene expression signatures correspond to the gut dysbiosis and neurodegenerative phenotypes. Here, APOE is linked to Alzheimer disease.