Likewise, the mRNA expression levels of the signature genes for hair inductivity such as BMP4, HEY1, and WIF1 were markedly increased in MS275 treated DCs (Fig. 2d), and the HF reconstitution assay showed that DCs cultured with MS275 were able to successfully reconstitute HFs even after 5 days of culture (Fig. 3a). Here, BMP4 is linked to hydrops fetalis.