Inheritance factors may also be of importance41, with eight different genetic loci (i.e. TCF7L2, GCK, KCNJ11, KCNQ1, CDKAL1, IGF2BP2, MTNR1B and IRS1) being associated with both increased risk of GDM and T2DM42. This evidence concerns the gene CDKAL1 and gestational diabetes.